Research workbench
Products in the T state of aspartate transcarbamylase: crystal structure of the phosphate and N-carbamyl-L-aspartate ligated enzyme
Analyse Products in the T state of aspartate transcarbamylase: crystal structure of the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1R0C
- Type
- protein
- Length
- 926 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aspartate carbamoyltransferase catalytic chain; Aspartate carbamoyltransferase regulatory…
- EC
- 2.1.3.2
- UniProt
- P0A786, P0A7F3
- Ligands
- NCD, ZN, PO4
- Pockets
- 10 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, G | Aspartate carbamoyltransferase catalytic chain (EC 2.1.3.2) | protein | 310 | 41% helix, 17% strand | P0A786 |
| B, H | Aspartate carbamoyltransferase regulatory chain | protein | 153 | 10% helix, 35% strand | P0A7F3 |
Ligands and binding sites
- NCD · N-carbamoyl-L-aspartate · ligand · 2 copies · chains A, G
- ZN · Zinc ion · metal · 2 copies · chains B, H
- PO4 · Phosphate ion · ion · 2 copies · chains A, G
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 331 | 0.61 | 0.79 | 31 | PO4 |
| 2 | 319 | 0.61 | 0.79 | 27 | PO4 |
| 3 | 116 | 0.48 | 0.79 | 23 | empty |
| 4 | 150 | 0.47 | 0.77 | 31 | empty |
| 5 | 139 | 0.46 | 0.77 | 27 | empty |
Interfaces
3 interfaces between chains.
- B–H · 1161 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 666 Ų buried · 15 hydrogen bonds · protein-protein
- G–H · 656 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 1R0C · Products in the T State of Aspartate Transcarbamylase: Crystal Structure of the Phosphate… · the same entry in another collection · chain A against A, TM-score 1.00
- P0A786 · AlphaFold monomer V2.0 prediction for aspartate carbamoyltransferase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P0A7F3 · AlphaFold monomer V2.0 prediction for aspartate carbamoyltransferase regulatory chain… · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A786
- Every structure of UniProt P0A7F3
- Elsewhere: RCSB PDB 1R0C · PDBe 1R0C · UniProt P0A786 · UniProt P0A7F3
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