Research workbench
Crystal structure of apocam bound to the gating domain of small conductance CA2+-activated potassium channel
Analyse Crystal structure of apocam bound to the gating domain of small conductance… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QX7
- Type
- protein
- Length
- 697 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Small conductance calcium-activated potassium channel protein 2
- UniProt
- P62161, P70604
- Pockets
- 10 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 53% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| I, R, A | Calmodulin | protein | 145 | 60% helix, 7% strand | P62161 |
| B | Calmodulin | protein | 136 | 54% helix, 6% strand | P62161 |
| M | Calmodulin | protein | 115 | 40% helix, 3% strand | P62161 |
| D | Small conductance calcium-activated potassium channel protein 2 | protein | 11 | 82% helix, 0% strand | P70604 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1104 | 0.80 | 0.81 | 126 | empty |
| 2 | 694 | 0.72 | 0.79 | 72 | empty |
| 3 | 144 | 0.58 | 0.83 | 25 | empty |
| 4 | 131 | 0.44 | 0.77 | 28 | empty |
| 5 | 119 | 0.42 | 0.77 | 27 | empty |
Interfaces
10 interfaces between chains.
- A–B · 2647 Ų buried · 44 hydrogen bonds · protein-protein
- I–R · 2631 Ų buried · 36 hydrogen bonds · protein-protein
- I–A · 614 Ų buried · 5 hydrogen bonds · protein-protein
- R–M · 497 Ų buried · 9 hydrogen bonds · protein-protein
- M–D · 427 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 43 modified (engineered).
Compared structures
- 1QX7 · Crystal structure of apoCaM bound to the gating domain of small conductance… · the same entry in another collection · chain R against R, TM-score 1.00
- P70604 · AlphaFold monomer V2.0 prediction for small conductance calcium- activated potassium… · a predicted model of the same protein · chain D against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62161
- Every structure of UniProt P70604
- Elsewhere: RCSB PDB 1QX7 · PDBe 1QX7 · UniProt P62161 · UniProt P70604
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