Research workbench
Mechanism of G1 cyclin dependent kinase inhibition from the structure of the CDK6-P16INK4A tumor suppressor complex
Analyse Mechanism of G1 cyclin dependent kinase inhibition from the structure of the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1BI7
- Type
- protein
- Length
- 394 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclin-dependent kinase 6; Multiple tumor suppressor
- EC
- 2.7.1.-
- UniProt
- Q00534, P42771
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cyclin-dependent kinase 6 (EC 2.7.1.-) | protein | 269 | 32% helix, 20% strand | Q00534 |
| B | Multiple tumor suppressor | protein | 125 | 46% helix, 0% strand | P42771 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 250 | 0.61 | 0.80 | 24 | empty |
| 2 | 192 | 0.49 | 0.76 | 23 | empty |
| 3 | 131 | 0.46 | 0.77 | 19 | empty |
| 4 | 99 | 0.37 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1278 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 1BI7 · Mechanism of G1 cyclin dependent kinase inhibition from the structure of the… · the same entry in another collection · chain A against A, TM-score 1.00
- P42771 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase inhibitor 2A (P42771) · a predicted model of the same protein · chain B against A, TM-score 0.96
- Q00534 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 6 (Q00534) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00534
- Every structure of UniProt P42771
- Elsewhere: RCSB PDB 1BI7 · PDBe 1BI7 · UniProt Q00534 · UniProt P42771
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