UniProt P42771
Cyclin-dependent kinase inhibitor 2A (P42771)
Cyclin-dependent kinase inhibitor 2A (UniProt P42771): 9 experimental structures and 1 predicted model on GenesisL1, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P42771
- Protein
- Cyclin-dependent kinase inhibitor 2A
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 1 · 0 records with a druggable one
Structures
10 records of P42771 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A5E | Solution NMR structure of tumor suppressor P16INK4A, 18 structures | solution nmr | A | — | — |
| 1A5E | Solution NMR structure of tumor suppressor P16INK4A, 18 structures | solution nmr | A | — | — |
| 1BI7 | Mechanism of G1 cyclin dependent kinase inhibition from the structure of the CDK6-P16INK4A tumor… | x-ray diffraction | B | — | — |
| 1BI7 | Mechanism of G1 cyclin dependent kinase inhibition from the structure of the CDK6-P16INK4A tumor… | x-ray diffraction | B | — | — |
| 1DC2 | Solution NMR structure of tumor suppressor P16INK4A, 20 structures | solution nmr | A | — | — |
| 1DC2 | Solution NMR structure of tumor suppressor P16INK4A, 20 structures | solution nmr | A | — | — |
| 2A5E | Solution NMR structure of tumor suppressor P16INK4A, restrained minimized mean structure | solution nmr | A | — | — |
| 2A5E | Solution NMR structure of tumor suppressor P16INK4A, restrained minimized mean structure | solution nmr | A | — | — |
| 7OZT | Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a | x-ray diffraction | BBB | — | 1 (best 0.30) |
| P42771 | AlphaFold monomer V2.0 prediction for cyclin-dependent kinase inhibitor 2A (P42771) | predicted | A | — | — |
Experiment against prediction
- 7OZT chain BBB against the predicted model P42771: TM-score 0.98, RMSD 0.59 Å
- 1BI7 chain B against the predicted model P42771: TM-score 0.96, RMSD 0.86 Å
- 1BI7 chain B against the predicted model P42771: TM-score 0.96, RMSD 0.86 Å
- 1DC2 chain A against the predicted model P42771: TM-score 0.78, RMSD 2.31 Å
- 1DC2 chain A against the predicted model P42771: TM-score 0.78, RMSD 2.31 Å
- 2A5E chain A against the predicted model P42771: TM-score 0.76, RMSD 2.08 Å
- 2A5E chain A against the predicted model P42771: TM-score 0.76, RMSD 2.08 Å
- 1A5E chain A against the predicted model P42771: TM-score 0.75, RMSD 2.25 Å
- 1A5E chain A against the predicted model P42771: TM-score 0.75, RMSD 2.25 Å
Elsewhere
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