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Crystal structure of the ap-2 clathrin adaptor alpha- appendage

Analyse Crystal structure of the ap-2 clathrin adaptor alpha- appendage in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1QTP
Type: protein
Length: 247 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ap-2 clathrin adaptor alpha subunit (alpha- adaptin C)
UniProt: P17427
Pockets: 3 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 19% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ap-2 clathrin adaptor alpha subunit (alpha- adaptin C)	protein	247	19% helix, 43% strand	P17427

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.35	0.75	15	empty
2	67	0.33	0.76	16	empty
3	52	0.27	0.74	14	empty

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

1QTP · Crystal structure of the ap-2 clathrin adaptor alpha-appendage · the same entry in another collection · chain A against A, TM-score 1.00
P17427 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit alpha-2 (P17427) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17427
Elsewhere: RCSB PDB 1QTP · PDBe 1QTP · UniProt P17427

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