Research workbench
Structure of human A6-TCR bound to HLA-A2 complexed with altered HTLV- 1 tax peptide V7R
Analyse Structure of human A6-TCR bound to HLA-A2 complexed with altered HTLV- 1 tax… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QSE
- Type
- protein
- Length
- 826 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (MHC class I HLA-a); Protein (beta-2 microglobulin); Tax peptide V7R; Protein…
- UniProt
- P01892, P61769
- Pockets
- 11 · best druggability 0.70
Structure
x-ray diffraction · 5 distinct chains · 12% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (MHC class I HLA-a) | protein | 274 | 27% helix, 38% strand | P01892 |
| B | Protein (beta-2 microglobulin) | protein | 100 | 0% helix, 49% strand | P61769 |
| C | Tax peptide V7R | protein | 9 | 0% helix, 0% strand | — |
| D | Protein (human T-cell receptor) | protein | 200 | 5% helix, 45% strand | — |
| E | Protein (human T-cell receptor) | protein | 243 | 7% helix, 47% strand | — |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 968 | 0.70 | 0.75 | 77 | empty |
| 2 | 629 | 0.68 | 0.77 | 53 | empty |
| 3 | 138 | 0.54 | 0.82 | 30 | empty |
| 4 | 113 | 0.51 | 0.81 | 21 | empty |
| 5 | 89 | 0.45 | 0.80 | 20 | empty |
Interfaces
7 interfaces between chains.
- D–E · 2112 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1339 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 855 Ų buried · 13 hydrogen bonds · protein-protein
- A–D · 600 Ų buried · 5 hydrogen bonds · protein-protein
- C–E · 249 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 1QSE · Structure of human A6-TCR bound to HLA-A2 complexed with altered HTLV-1 tax peptide V7R · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01892
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 1QSE · PDBe 1QSE · UniProt P01892 · UniProt P61769
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