Research workbench
Structure of a voltage-dependent K+ channel beta subunit
Analyse Structure of a voltage-dependent K+ channel beta subunit in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QRQ
- Type
- protein
- Length
- 1,300 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (kv BETA2 protein)
- UniProt
- P62483
- Ligands
- NDP
- Pockets
- 15 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Protein (kv BETA2 protein) | protein | 325 | 50% helix, 17% strand | P62483 |
Ligands and binding sites
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 800 | 0.82 | 0.85 | 41 | empty |
| 2 | 224 | 0.78 | 0.92 | 40 | NDP |
| 3 | 232 | 0.76 | 0.90 | 41 | NDP |
| 4 | 305 | 0.75 | 0.87 | 55 | NDP |
| 5 | 319 | 0.74 | 0.86 | 61 | NDP |
Interfaces
4 interfaces between chains.
- A–C · 965 Ų buried · 23 hydrogen bonds · protein-protein
- B–C · 959 Ų buried · 23 hydrogen bonds · protein-protein
- B–D · 958 Ų buried · 22 hydrogen bonds · protein-protein
- A–D · 948 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 1QRQ · Structure of a voltage-dependent K+ channel beta subunit · the same entry in another collection · chain A against A, TM-score 1.00
- P62483 · AlphaFold monomer V2.0 prediction for voltage-gated potassium channel subunit beta-2… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62483
- Elsewhere: RCSB PDB 1QRQ · PDBe 1QRQ · UniProt P62483
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