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Crystal structure of the pH-ptb targeting region of irs-1

Analyse Crystal structure of the pH-ptb targeting region of irs-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1QQG
Type: protein
Length: 417 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin receptor substrate 1
UniProt: P35568
Pockets: 3 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Insulin receptor substrate 1	protein	207	23% helix, 44% strand	P35568
B	Insulin receptor substrate 1	protein	210	24% helix, 41% strand	P35568

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	278	0.68	0.83	29	empty
2	160	0.57	0.82	27	empty
3	155	0.56	0.81	26	empty

Interfaces

1 interface between chains.

A–B · 696 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

1QQG · Crystal structure of the pH-ptb targeting region of irs-1 · the same entry in another collection · chain A against A, TM-score 1.00
P35568 · AlphaFold monomer V2.0 prediction for insulin receptor substrate 1 (P35568) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35568
Elsewhere: RCSB PDB 1QQG · PDBe 1QQG · UniProt P35568

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