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Truncated form of casein kinase II beta subunit (2-182) from homo sapiens

Analyse Truncated form of casein kinase II beta subunit (2-182) from homo sapiens in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1QF8
Type
protein
Length
330 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Casein kinase II
EC
2.7.1.37
UniProt
P67870
Ligands
ZN, MG
Pockets
1 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 8% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ACasein kinase II (EC 2.7.1.37)protein16748% helix, 8% strandP67870
BCasein kinase II (EC 2.7.1.37)protein16348% helix, 8% strandP67870

Ligands and binding sites

  • ZN · Zinc ion · metal · 2 copies · chains A, B
  • MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12140.590.8137empty

Interfaces

1 interface between chains.

  • A–B · 576 Ų buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 modified (engineered).

Compared structures

  • 1QF8 · Truncated form of casein kinase II beta subunit (2-182) from homo sapiens · the same entry in another collection · chain A against A, TM-score 1.00
  • P67870 · AlphaFold monomer V2.0 prediction for casein kinase II subunit beta (P67870) · a predicted model of the same protein · chain B against A, TM-score 0.99

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