Research workbench
Cleaved substrate variant of plasminogen activator inhibitor-1
Analyse Cleaved substrate variant of plasminogen activator inhibitor-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 9PAI
- Type
- protein
- Length
- 379 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (plasminogen activator inhibitor-1) residues 19- 364; Protein (plasminogen…
- UniProt
- P05121
- Pockets
- 2 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (plasminogen activator inhibitor-1) residues 19- 364 | protein | 346 | 32% helix, 33% strand | P05121 |
| B | Protein (plasminogen activator inhibitor-1) residues 365- 397 | protein | 33 | 0% helix, 55% strand | P05121 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.37 | 0.79 | 22 | empty |
| 2 | 55 | 0.29 | 0.75 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 2404 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 9PAI · Cleaved substrate variant of plasminogen activator inhibitor-1 · the same entry in another collection · chain A against A, TM-score 1.00
- P05121 · AlphaFold monomer V2.0 prediction for plasminogen activator inhibitor 1 (P05121) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05121
- Elsewhere: RCSB PDB 9PAI · PDBe 9PAI · UniProt P05121
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