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Triose phosphate isomerase

Analyse Triose phosphate isomerase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 8TIM
Type: protein
Length: 494 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Triose phosphate isomerase
EC: 5.3.1.1
UniProt: P00940
Ligands: SO4
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Triose phosphate isomerase (EC 5.3.1.1)	protein	247	46% helix, 17% strand	P00940

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	145	0.68	0.89	39	empty
2	170	0.45	0.75	33	SO4
3	103	0.43	0.78	25	SO4
4	50	0.28	0.75	19	empty

Interfaces

1 interface between chains.

A–B · 1677 Å² buried · 30 hydrogen bonds · protein-protein

Compared structures

8TIM · Triose phosphate isomerase · the same entry in another collection · chain A against A, TM-score 1.00
P00940 · AlphaFold monomer V2.0 prediction for triosephosphate isomerase (P00940) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00940
Elsewhere: RCSB PDB 8TIM · PDBe 8TIM · UniProt P00940

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