Research workbench
Crystal structure of the conserved subdomain of human protein SRP54M at 2.1A resolution: evidence for the mechanism of signal peptide binding
Analyse Crystal structure of the conserved subdomain of human protein SRP54M at 2.1A… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1QB2
- Type
- protein
- Length
- 215 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Human signal recognition particle 54 kd protein
- UniProt
- P61011
- Pockets
- 2 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Human signal recognition particle 54 kd protein | protein | 106 | 70% helix, 0% strand | P61011 |
| B | Human signal recognition particle 54 kd protein | protein | 109 | 69% helix, 2% strand | P61011 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 89 | 0.62 | 0.89 | 22 | empty |
| 2 | 50 | 0.31 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 2410 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 1QB2 · Crystal structure of the conserved subdomain of human protein SRP54M at 2.1A resolution… · the same entry in another collection · chain A against A, TM-score 1.00
- P61011 · AlphaFold monomer V2.0 prediction for signal recognition particle 54 kda protein (P61011) · a predicted model of the same protein · chain A against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61011
- Elsewhere: RCSB PDB 1QB2 · PDBe 1QB2 · UniProt P61011
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