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Crystal structure of ATP-dependent RNA helicase DDX42

Analyse Crystal structure of ATP-dependent RNA helicase DDX42 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 8DPE
Type: protein
Length: 436 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent RNA helicase DDX42
EC: 3.6.4.13
UniProt: Q86XP3
Pockets: 2 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-dependent RNA helicase DDX42 (EC 3.6.4.13)	protein	436	45% helix, 16% strand	Q86XP3

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	577	0.70	0.79	58	empty
2	50	0.28	0.76	15	empty

Compared structures

8DPE · Crystal structure of ATP-dependent RNA helicase DDX42 · the same entry in another collection · chain A against A, TM-score 1.00
Q86XP3 · AlphaFold monomer V2.0 prediction for ATP-dependent RNA helicase DDX42 (Q86XP3) · a predicted model of the same protein · chain A against A, TM-score 0.61

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86XP3
Elsewhere: RCSB PDB 8DPE · PDBe 8DPE · UniProt Q86XP3

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