Research workbench
Local refinement of RHAG/CE trimer in class 2 of erythrocyte ankyrin-1 complex
Analyse Local refinement of RHAG/CE trimer in class 2 of erythrocyte ankyrin-1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8CSX
- Type
- protein
- Length
- 1,158 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Blood group RH(CE) polypeptide; Ammonium transporter rh type a
- UniProt
- P18577, Q02094
- Ligands
- CLR, AJP
- Pockets
- 20 · best druggability 0.78
Structure
electron microscopy · 3 distinct chains · 73% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| K | Blood group RH(CE) polypeptide | protein | 380 | 72% helix, 3% strand | P18577 |
| L | Ammonium transporter rh type a | protein | 388 | 72% helix, 2% strand | Q02094 |
| Q | Ammonium transporter rh type a | protein | 390 | 74% helix, 2% strand | Q02094 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 102 | 0.78 | 0.97 | 28 | empty |
| 2 | 81 | 0.76 | 0.98 | 19 | empty |
| 3 | 53 | 0.68 | 0.96 | 20 | empty |
| 4 | 414 | 0.64 | 0.78 | 36 | empty |
| 5 | 258 | 0.63 | 0.81 | 39 | empty |
Interfaces
3 interfaces between chains.
- K–L · 2884 Ų buried · 22 hydrogen bonds · protein-protein
- L–Q · 2698 Ų buried · 30 hydrogen bonds · protein-protein
- K–Q · 2525 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 8CSX · Local refinement of RhAG/CE trimer in class 2 of erythrocyte ankyrin-1 complex · the same entry in another collection · chain K against K, TM-score 1.00
- Q02094 · AlphaFold monomer V2.0 prediction for ammonium transporter rh type a (Q02094) · a predicted model of the same protein · chain L against A, TM-score 1.00
- P18577 · AlphaFold monomer V2.0 prediction for blood group RH(CE) polypeptide (P18577) · a predicted model of the same protein · chain K against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18577
- Every structure of UniProt Q02094
- Elsewhere: RCSB PDB 8CSX · PDBe 8CSX · UniProt P18577 · UniProt Q02094
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