Dithiol-ligand bound to streptavidin

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 54% strand (DSSP).

Ligands and binding sites

• K9R · 5-[(3~{A}~{S},4~{S},6~{A}~{R})-2-oxidanylidene-1,3, 3~{A},4,6,6~{A}-hexahydrothieno[3,4-d]imidazol-4-yl]-~{N}-[(1~{R},3~{S})-3-[3,5-bis(sulfanylmethyl)phenyl]-2,4-bis(oxidanylidene)cyclopentyl]pentanamide · ligand · 2 copies · chains A, B
• PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 539 Ų buried · 2 hydrogen bonds · protein-protein

Compared structures

• 7ZXZ · dithiol-ligand bound to streptavidin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P22629
• Elsewhere: RCSB PDB 7ZXZ · PDBe 7ZXZ · UniProt P22629