Human gabarap in complex with stapled peptide PEN3-ortho

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 21% strand (DSSP).

Ligands and binding sites

• OXE · Ortho-xylene · ligand · chains A, B
• PO4 · Phosphate ion · ion · 3 copies · chains A
• NH2 · Amino group · ion · chains B
• CL · Chloride ion · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 620 Ų buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent, 1 modified (covalent ligand, nonstandard).

Compared structures

• 7ZKR · Human GABARAP in complex with stapled peptide Pen3-ortho · the same entry in another collection · chain A against A, TM-score 1.00
• O95166 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated protein… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O95166
• Elsewhere: RCSB PDB 7ZKR · PDBe 7ZKR · UniProt O95166