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Crystal structure of the histone domain of son of sevenless

Analyse Crystal structure of the histone domain of son of sevenless in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1Q9C
Type: protein
Length: 1,553 residues
Chains: 9
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Son of sevenless protein
UniProt: Q07889
Pockets: 13 · best druggability 0.76

Structure

x-ray diffraction · 8 distinct chains · 65% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Son of sevenless protein	protein	164	68% helix, 1% strand	Q07889
B	Son of sevenless protein	protein	172	66% helix, 1% strand	Q07889
C	Son of sevenless protein	protein	162	69% helix, 1% strand	Q07889
D, I	Son of sevenless protein	protein	178	64% helix, 1% strand	Q07889
E	Son of sevenless protein	protein	176	62% helix, 1% strand	Q07889
F	Son of sevenless protein	protein	174	64% helix, 2% strand	Q07889
G	Son of sevenless protein	protein	174	62% helix, 1% strand	Q07889
H	Son of sevenless protein	protein	175	66% helix, 2% strand	Q07889

Pockets

13 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1105	0.76	0.79	100	empty
2	596	0.72	0.79	72	empty
3	657	0.71	0.78	75	empty
4	782	0.71	0.77	58	empty
5	675	0.71	0.78	78	empty

Interfaces

15 interfaces between chains.

E–F · 519 Å² buried · 10 hydrogen bonds · protein-protein
B–C · 493 Å² buried · 7 hydrogen bonds · protein-protein
D–E · 465 Å² buried · 9 hydrogen bonds · protein-protein
H–I · 447 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 447 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 36 modified (engineered).

Compared structures

1Q9C · Crystal Structure of the Histone domain of Son of Sevenless · the same entry in another collection · chain I against I, TM-score 1.00
Q07889 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07889
Elsewhere: RCSB PDB 1Q9C · PDBe 1Q9C · UniProt Q07889

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