Research workbench
Crystal structure of TRIM7 bound to 2C
Analyse Crystal structure of TRIM7 bound to 2C in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7Y3A
- Type
- protein
- Length
- 540 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein…
- EC
- 2.3.2.27
- UniProt
- Q9C029
- Pockets
- 6 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,TRIM7-2C (EC 2.3.2.27) | protein | 181 | 2% helix, 40% strand | Q9C029 |
| B | E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,TRIM7-2C (EC 2.3.2.27) | protein | 178 | 4% helix, 42% strand | Q9C029 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 156 | 0.56 | 0.81 | 32 | empty |
| 2 | 119 | 0.52 | 0.82 | 21 | empty |
| 3 | 50 | 0.39 | 0.81 | 15 | empty |
| 4 | 97 | 0.38 | 0.76 | 19 | empty |
| 5 | 74 | 0.32 | 0.75 | 18 | empty |
Interfaces
2 interfaces between chains.
- A–B · 717 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 696 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9C029
- Elsewhere: RCSB PDB 7Y3A · PDBe 7Y3A · UniProt Q9C029
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.