UniProt Q9C029
E3 ubiquitin-protein ligase TRIM7 (Q9C029)
E3 ubiquitin-protein ligase TRIM7 (UniProt Q9C029), EC 2.3.2.27: 35 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9C029
- Protein
- E3 ubiquitin-protein ligase TRIM7
- EC
- 2.3.2.27
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 36 · 8 records with a druggable one
Structures
36 records of Q9C029 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6UMA | Crystal structure of the TRIM7 B30.2 domain at 1.6 angstrom resolution | x-ray diffraction | A, B | — | 3 (best 0.54) |
| 6UMA | Crystal structure of the TRIM7 B30.2 domain at 1.6 ångström resolution | x-ray diffraction | A, B | — | — |
| 6UMB | Crystal structure of TRIM7 B30.2 domain at 1.8 angstrom resolution | x-ray diffraction | A, B | — | 1 (best 0.29) |
| 6UMB | Crystal structure of TRIM7 B30.2 domain at 1.8 ångström resolution | x-ray diffraction | A, B | — | — |
| 7OVX | E3 RING ligase binding domain | x-ray diffraction | A | — | 1 (best 0.30) |
| 7OVX | E3 ring ligase binding domain | x-ray diffraction | A | — | — |
| 7OW2 | E3 RING ligase binding domain with peptide | x-ray diffraction | A, B, C, D | CL, PO4 | 5 (best 0.74) |
| 7OW2 | E3 ring ligase binding domain with peptide | x-ray diffraction | A, B, C, D | CL, PO4 | — |
| 7W0Q | TRIM7 in complex with C-terminal peptide of 2C | x-ray diffraction | A | — | 1 (best 0.38) |
| 7W0Q | TRIM7 in complex with C-terminal peptide of 2C | x-ray diffraction | A | — | — |
| 7W0S | TRIM7 in complex with C-terminal peptide of 2C | x-ray diffraction | B, C, E | NO3 | 3 (best 0.62) |
| 7W0S | TRIM7 in complex with C-terminal peptide of 2C | x-ray diffraction | B, C, E | NO3 | — |
| 7W0T | TRIM7 in complex with C-terminal peptide of 2C | x-ray diffraction | F, C, B | — | 5 (best 0.60) |
| 7W0T | TRIM7 in complex with C-terminal peptide of 2C | x-ray diffraction | F, C, B | — | — |
| 7X6Y | TRIM7 in complex with C-terminal peptide of NSP5 | x-ray diffraction | A | — | — |
| 7X6Y | TRIM7 in complex with C-terminal peptide of NSP5 | x-ray diffraction | A | — | — |
| 7X6Z | TRIM7 in complex with C-terminal peptide of NSP12 | x-ray diffraction | A | — | — |
| 7X6Z | TRIM7 in complex with C-terminal peptide of NSP12 | x-ray diffraction | A | — | — |
| 7X70 | TRIM7 in complex with C-terminal peptide of NSP8 | x-ray diffraction | A | — | — |
| 7X70 | TRIM7 in complex with C-terminal peptide of NSP8 | x-ray diffraction | A | — | — |
| 7Y3A | Crystal structure of TRIM7 bound to 2C | x-ray diffraction | A, C, B | — | 6 (best 0.56) |
| 7Y3A | Crystal structure of TRIM7 bound to 2C | x-ray diffraction | A, C, B | — | — |
| 7Y3B | Crystal structure of TRIM7 bound to GN1 | x-ray diffraction | A | — | 1 (best 0.31) |
| 7Y3B | Crystal structure of TRIM7 bound to GN1 | x-ray diffraction | A | — | — |
| 7Y3C | Crystal structure of TRIM7 bound to RACO-1 | x-ray diffraction | A | — | 1 (best 0.33) |
| 7Y3C | Crystal structure of TRIM7 bound to raco-1 | x-ray diffraction | A | — | — |
| 8A5L | TRIM7 PRYSPRY in complex with a 2BC peptide TIEALFQ | x-ray diffraction | A | — | 1 (best 0.24) |
| 8A5L | TRIM7 pryspry in complex with a 2BC peptide tiealfq | x-ray diffraction | A | — | — |
| 8A5M | TRIM7 PRYSPRY in complex with a MNV1-NS6 peptide LEALEFQ | x-ray diffraction | A, B | PO4 | 4 (best 0.54) |
| 8A5M | TRIM7 pryspry in complex with a MNV1-NS6 peptide lealefq | x-ray diffraction | A, B | PO4 | — |
| 8A8X | TRIM7 PRYSPRY in complex with a MNV1-NS3 peptide HDDFGLQ | x-ray diffraction | A, C | — | 1 (best 0.45) |
| 8A8X | TRIM7 pryspry in complex with a MNV1-NS3 peptide hddfglq | x-ray diffraction | A, C | — | — |
| 8R5B | Crystal structure of human TRIM7 PRYSPRY domain bound to (3-phenoxybenzoyl)-L-glutamine | x-ray diffraction | A, B | Y32 | 1 (best 0.78) |
| 8R5C | Crystal structure of human TRIM7 PRYSPRY domain bound to… | x-ray diffraction | A | Y3C, SRT | — |
| 8R5D | Crystal structure of human TRIM7 PRYSPRY domain | x-ray diffraction | A, B | — | 1 (best 0.72) |
| Q9C029 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase TRIM7 (Q9C029) | predicted | A | — | 1 (best 0.44) |
Ligands
- PO4 · Phosphate ion · in 4 records
- CL · Chloride ion · in 2 records
- NO3 · Nitrate ion · in 2 records
- SRT · S,R meso-tartaric acid · in 1 record
- Y32 · (2~{S})-5-azanyl-5-oxidanylidene-2-[(3-phenoxyphenyl)carbonylamino]pentanoic acid · in 1 record
- Y3C · (2~{S})-5-azanyl-5-oxidanylidene-2-[[(2~{S})-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)-3-phenyl-propanoyl]amino]pentanoic acid · in 1 record
Experiment against prediction
- 7OW2 chain B against the predicted model Q9C029: TM-score 0.99, RMSD 0.57 Å
- 7OW2 chain B against the predicted model Q9C029: TM-score 0.99, RMSD 0.57 Å
- 7W0T chain F against the predicted model Q9C029: TM-score 0.99, RMSD 0.58 Å
- 7W0T chain F against the predicted model Q9C029: TM-score 0.99, RMSD 0.58 Å
- 8R5B chain A against the predicted model Q9C029: TM-score 0.99, RMSD 0.60 Å
- 7W0S chain B against the predicted model Q9C029: TM-score 0.99, RMSD 0.61 Å
- 7W0S chain B against the predicted model Q9C029: TM-score 0.99, RMSD 0.61 Å
- 8A5M chain B against the predicted model Q9C029: TM-score 0.99, RMSD 0.60 Å
- 8A5M chain B against the predicted model Q9C029: TM-score 0.99, RMSD 0.60 Å
- 7X6Y chain A against the predicted model Q9C029: TM-score 0.98, RMSD 0.63 Å
Elsewhere
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