MolNFT v1 · #189859 · protein

TRIM7 in complex with C-terminal peptide of 2C

7W0Q · E3 ubiquitin-protein ligase TRIM7: “TRIM7 in complex with C-terminal peptide of 2C”. X-ray diffraction, 1 pocket (best druggability 0.38). MolNFT v1 #189859 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7W0Q
Type: protein
Length: 183 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: E3 ubiquitin-protein ligase TRIM7; Peptide
EC: 2.3.2.27
UniProt: Q9C029
Pockets: 1 · best druggability 0.38

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 ubiquitin-protein ligase TRIM7 (EC 2.3.2.27)	protein	173	2% helix, 42% strand	Q9C029
B	Peptide	protein	10	40% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	80	0.38	0.78	18	empty

Interfaces

1 interface between chains.

A–B · 431 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

7W0Q · TRIM7 in complex with C-terminal peptide of 2C · the same entry in another collection · chain A against A, TM-score 1.00
Q9C029 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase TRIM7 (Q9C029) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9C029
Elsewhere: RCSB PDB 7W0Q · PDBe 7W0Q · UniProt Q9C029

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