Research workbench

Complex of echo 18 and fcrn at PH7.4

Analyse Complex of echo 18 and fcrn at PH7.4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7XXA
Type: protein
Length: 950 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: VP1; IgG receptor fcrn large subunit P51; VP2; VP3; VP4
UniProt: P55899
Pockets: 7 · best druggability 0.62

Structure

electron microscopy · 5 distinct chains · 14% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	VP1	protein	276	10% helix, 26% strand	—
E	IgG receptor fcrn large subunit P51	protein	144	39% helix, 33% strand	P55899
B	VP2	protein	250	10% helix, 36% strand	—
C	VP3	protein	238	8% helix, 30% strand	—
D	VP4	protein	42	14% helix, 2% strand	—

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	157	0.62	0.85	36	empty
2	257	0.62	0.80	40	empty
3	103	0.42	0.77	17	empty
4	56	0.41	0.82	14	empty
5	54	0.35	0.79	13	empty

Interfaces

9 interfaces between chains.

A–C · 4445 Å² buried · 79 hydrogen bonds · protein-protein
A–B · 2096 Å² buried · 35 hydrogen bonds · protein-protein
B–C · 1698 Å² buried · 27 hydrogen bonds · protein-protein
A–D · 1239 Å² buried · 24 hydrogen bonds · protein-protein
C–D · 1018 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

7XXA · Complex of Echo 18 and FcRn at pH7.4 · the same entry in another collection · chain A against A, TM-score 1.00
P55899 · AlphaFold monomer V2.0 prediction for IgG receptor fcrn large subunit P51 (P55899) · a predicted model of the same protein · chain E against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55899
Elsewhere: RCSB PDB 7XXA · PDBe 7XXA · UniProt P55899

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