UniProt P55899
IgG receptor FcRn large subunit p51 (P55899)
IgG receptor FcRn large subunit p51 (UniProt P55899): 36 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P55899
- Protein
- IgG receptor FcRn large subunit p51
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 20 · 4 records with a druggable one
Structures
37 records of P55899 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EXU | Crystal structure of the human MHC-related Fc receptor | x-ray diffraction | A | — | — |
| 1EXU | Crystal structure of the human MHC-related Fc receptor | x-ray diffraction | A | — | — |
| 3M17 | Crystal structure of human FcRn with a monomeric peptide inhibitor | x-ray diffraction | A, C, E, G | — | — |
| 3M17 | Crystal structure of human fcrn with a monomeric peptide inhibitor | x-ray diffraction | A, C, E, G | — | — |
| 3M1B | Crystal structure of human FcRn with a dimeric peptide inhibitor | x-ray diffraction | A, C, E, G | — | — |
| 3M1B | Crystal structure of human fcrn with a dimeric peptide inhibitor | x-ray diffraction | A, C, E, G | — | — |
| 4K71 | Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor | x-ray diffraction | B, E | — | — |
| 4K71 | Crystal structure of a high affinity human serum albumin variant bound to the neonatal Fc receptor | x-ray diffraction | B, E | — | — |
| 4N0F | Human FcRn complexed with human serum albumin | x-ray diffraction | A, E, H, K | — | — |
| 4N0F | Human fcrn complexed with human serum albumin | x-ray diffraction | A, E, H, K | — | — |
| 4N0U | Ternary complex between Neonatal Fc receptor, serum albumin and Fc | x-ray diffraction | A | — | — |
| 4N0U | Ternary complex between neonatal Fc receptor, serum albumin and Fc | x-ray diffraction | A | — | — |
| 5BJT | Crystal structure of human FcRn with a peptide inhibitor at multiple sites | x-ray diffraction | A, C, E, G | — | — |
| 5BJT | Crystal structure of human fcrn with a peptide inhibitor at multiple sites | x-ray diffraction | A, C, E, G | — | — |
| 5BXF | Apo fcrn structure at pH 4.5 | x-ray diffraction | A, C | — | — |
| 5WHK | Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M | x-ray diffraction | A | — | 6 (best 0.71) |
| 5WHK | Crystal structure of Fab fragment of antibody dx-2507 bound to fcrn- B2M | x-ray diffraction | A | — | — |
| 6C97 | Crystal structure of FcRn at pH3 | x-ray diffraction | A, C | — | — |
| 6C97 | Crystal structure of fcrn at PH3 | x-ray diffraction | A, C | — | — |
| 6C98 | Crystal structure of fcrn bound to ucb-84 | x-ray diffraction | A, C | ER7 | — |
| 6C99 | Crystal structure of fcrn bound to ucb-303 | x-ray diffraction | A, C | EQY, NAG | — |
| 6FGB | Human FcRn extra-cellular domain complexed with Fab fragment of Rozanolixizumab | x-ray diffraction | A | CL, NA | 6 (best 0.70) |
| 6FGB | Human fcrn extra-cellular domain complexed with Fab fragment of rozanolixizumab | x-ray diffraction | A | CL, NA | — |
| 6ILM | Cryo-EM structure of echovirus 6 complexed with its uncoating receptor fcrn at pH 7.4 | electron microscopy | E | — | — |
| 6LA6 | Cryo-EM structure of echovirus 11 complexed with its uncoating receptor fcrn at pH 7.4 | electron microscopy | E | — | — |
| 6LA7 | Cryo-EM structure of echovirus 11 complexed with its uncoating receptor fcrn at pH 5.5 | electron microscopy | E | — | — |
| 6NHA | Crystal structure of SYNT001, a human fcrn blocking monoclonal antibody | x-ray diffraction | A | — | — |
| 6QIO | Ternary complex of fcrn ectodomain, fcrn binding optimised human serum albumin and the human growth… | x-ray diffraction | B | — | — |
| 6QIP | Ternary complex of fcrn ectodomain, fcrn binding optimised human serum albumin and the… | x-ray diffraction | B | — | — |
| 6WNA | Next generation monomeric IGG4 Fc | x-ray diffraction | A | — | — |
| 6WOL | Next generation monomeric IgG4 Fc bound to neonatal Fc receptor | x-ray diffraction | A | — | 5 (best 0.63) |
| 6WOL | Next generation monomeric IGG4 Fc bound to neonatal Fc receptor | x-ray diffraction | A | — | — |
| 7B5F | Structure of echovirus 18 in complex with neonatal Fc receptor | electron microscopy | G | — | — |
| 7C9V | E30 F-particle in complex with fcrn | electron microscopy | E | — | — |
| 7XXA | Complex of Echo 18 and FcRn at pH7.4 | electron microscopy | E | — | 3 (best 0.62) |
| 7XXA | Complex of echo 18 and fcrn at PH7.4 | electron microscopy | E | — | — |
| P55899 | AlphaFold monomer V2.0 prediction for IgG receptor fcrn large subunit P51 (P55899) | predicted | A | — | — |
Ligands
- CL · Chloride ion · in 2 records
- NA · Sodium ion · in 2 records
- EQY · Methyl 7-(3,5-difluorophenyl)-5-(pyridin-3-yl)[1,2, 4]triazolo[1,5-a]pyrimidine-6-carboxylate · in 1 record
- ER7 · 1-[7-(3-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]ethan-1-one · in 1 record
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 1 record
Experiment against prediction
- 6C97 chain A against the predicted model P55899: TM-score 1.00, RMSD 0.38 Å
- 6C97 chain A against the predicted model P55899: TM-score 1.00, RMSD 0.38 Å
- 6C99 chain C against the predicted model P55899: TM-score 1.00, RMSD 0.40 Å
- 6WNA chain A against the predicted model P55899: TM-score 0.99, RMSD 0.45 Å
- 5BXF chain A against the predicted model P55899: TM-score 0.99, RMSD 0.49 Å
- 6WOL chain A against the predicted model P55899: TM-score 0.99, RMSD 0.50 Å
- 6WOL chain A against the predicted model P55899: TM-score 0.99, RMSD 0.50 Å
- 6FGB chain A against the predicted model P55899: TM-score 0.99, RMSD 0.50 Å
- 6FGB chain A against the predicted model P55899: TM-score 0.99, RMSD 0.50 Å
- 6C99 chain A against the predicted model P55899: TM-score 0.99, RMSD 0.51 Å
Elsewhere
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