Research workbench
Tshr-K1-70 complex
Analyse Tshr-K1-70 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7XW7
- Type
- protein
- Length
- 794 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- K1-70 scfv heavy chain; K1-70 scfv light chain; Thyrotropin receptor
- UniProt
- P16473
- Pockets
- 8 · best druggability 0.84
Structure
electron microscopy · 3 distinct chains · 31% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | K1-70 scfv heavy chain | protein | 118 | 3% helix, 51% strand | — |
| B | K1-70 scfv light chain | protein | 109 | 3% helix, 47% strand | — |
| R | Thyrotropin receptor | protein | 567 | 43% helix, 15% strand | P16473 |
Pockets
8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 719 | 0.84 | 0.88 | 141 | empty |
| 2 | 1132 | 0.79 | 0.80 | 148 | empty |
| 3 | 360 | 0.71 | 0.84 | 57 | empty |
| 4 | 814 | 0.71 | 0.77 | 101 | empty |
| 5 | 470 | 0.70 | 0.81 | 67 | empty |
Interfaces
3 interfaces between chains.
- A–B · 303 Ų buried · 0 hydrogen bonds · protein-protein
- B–R · 99 Ų buried · 0 hydrogen bonds · protein-protein
- A–R · 42 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16473
- Elsewhere: RCSB PDB 7XW7 · PDBe 7XW7 · UniProt P16473
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