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UniProt P16473

Thyrotropin receptor (P16473)

Thyrotropin receptor (UniProt P16473): 10 experimental structures on GenesisL1, 4 ligands bound, 16 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
P16473
Protein
Thyrotropin receptor
Experimental structures
10
Predicted models
0
Ligands
4
Pockets
16 · 2 records with a druggable one

Structures

10 records of P16473 in the MolNFT archive: 10 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
2XWTCrystal structure of the tsh receptor in complex with a blocking type tshr autoantibodyx-ray diffractionC——
2XWTCrystal structure of the tsh receptor in complex with a blocking type tshr autoantibodyx-ray diffractionC——
3G04Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibodyx-ray diffractionC——
3G04Crystal structure of the tsh receptor in complex with a thyroid- stimulating autoantibodyx-ray diffractionC——
7XW5TSHR-thyroid stimulating hormone-Gs-ML109 complexelectron microscopyRNAG, HOI, CLR, PLM12 (best 0.84)
7XW5Tshr-thyroid stimulating hormone-gs-ML109 complexelectron microscopyRNAG, HOI, CLR, PLM—
7XW6Tshr-gs-M22 antibody-ML109 complexelectron microscopyRNAG, CLR, PLM, HOI—
7XW7TSHR-K1-70 complexelectron microscopyR—4 (best 0.84)
7XW7Tshr-K1-70 complexelectron microscopyR——
P16473AlphaFold monomer V2.0 prediction for thyrotropin receptor (P16473)———

Ligands

  • CLR · Cholesterol · in 3 records
  • HOI · ~{N}-[4-[[2-methoxy-5-[(2~{S})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide · in 3 records
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
  • PLM · Palmitic acid · in 3 records

Elsewhere

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