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Crystal structure of human bleomycin hydrolase H372A mutant

Analyse Crystal structure of human bleomycin hydrolase H372A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7XF9
Type: protein
Length: 454 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bleomycin hydrolase
EC: 3.4.22.40
UniProt: Q13867
Pockets: 3 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bleomycin hydrolase (EC 3.4.22.40)	protein	454	43% helix, 17% strand	Q13867

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	116	0.55	0.83	23	empty
2	100	0.42	0.78	27	empty
3	87	0.36	0.75	19	empty

Compared structures

7XF9 · Crystal structure of human bleomycin hydrolase H372A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q13867 · AlphaFold monomer V2.0 prediction for bleomycin hydrolase (Q13867) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13867
Elsewhere: RCSB PDB 7XF9 · PDBe 7XF9 · UniProt Q13867

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