Research workbench
Human glyoxalase I (with C-ter his tag) in inhibitor-free form
Analyse Human glyoxalase I (with C-ter his tag) in inhibitor-free form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7WT1
- Type
- protein
- Length
- 352 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lactoylglutathione lyase
- EC
- 4.4.1.5
- UniProt
- Q04760
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Lactoylglutathione lyase (EC 4.4.1.5) | protein | 176 | 28% helix, 28% strand | Q04760 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 252 | 0.63 | 0.81 | 27 | empty |
| 2 | 252 | 0.63 | 0.80 | 30 | empty |
| 3 | 163 | 0.45 | 0.75 | 31 | empty |
| 4 | 143 | 0.43 | 0.76 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 3631 Ų buried · 48 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04760
- Elsewhere: RCSB PDB 7WT1 · PDBe 7WT1 · UniProt Q04760
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.