UniProt Q04760
Lactoylglutathione lyase (Q04760)
Lactoylglutathione lyase (UniProt Q04760), EC 4.4.1.5: 20 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q04760
- Protein
- Lactoylglutathione lyase
- EC
- 4.4.1.5
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 8 · 2 records with a druggable one
Structures
21 records of Q04760 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BH5 | Human glyoxalase I Q33E, E172Q double mutant | x-ray diffraction | A, B, C, D | — | — |
| 1BH5 | Human glyoxalase I Q33E, E172Q double mutant | x-ray diffraction | A, B, C, D | — | — |
| 1FRO | Human glyoxalase I with benzyl-glutathione inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 1FRO | Human glyoxalase I with benzyl-glutathione inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 1QIN | Human glyoxalase I complexed with S-(N-hydroxy-N-P-iodophenylcarbamoyl) glutathione | x-ray diffraction | A, B | — | — |
| 1QIN | Human glyoxalase I complexed with S-(N-hydroxy-N-P- iodophenylcarbamoyl) glutathione | x-ray diffraction | A, B | — | — |
| 1QIP | Human glyoxalase I complexed with S-P-nitrobenzyloxycarbonylglutathione | x-ray diffraction | A, B, C, D | — | — |
| 1QIP | Human glyoxalase I complexed with S-P- nitrobenzyloxycarbonylglutathione | x-ray diffraction | A, B, C, D | — | — |
| 3VW9 | Human Glyoxalase I with an N-hydroxypyridone inhibitor | x-ray diffraction | A, B | — | — |
| 3VW9 | Human glyoxalase I with an N-hydroxypyridone inhibitor | x-ray diffraction | A, B | — | — |
| 3W0T | Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 3W0T | Human glyoxalase I with an N-hydroxypyridone derivative inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 3W0U | human Glyoxalase I with an N-hydroxypyridone inhibitor | x-ray diffraction | A, B | — | — |
| 3W0U | Human glyoxalase I with an N-hydroxypyridone inhibitor | x-ray diffraction | A, B | — | — |
| 7WSZ | Human glyoxalase I (with C-ter his tag) in glycerol-bound form | x-ray diffraction | A, B | ZN, BO3 | — |
| 7WT0 | human glyoxalase I (with C-ter His tag) in complex with TLSC702 | x-ray diffraction | A, B | ZN, 5ZO | 4 (best 0.65) |
| 7WT0 | Human glyoxalase I (with C-ter his tag) in complex with TLSC702 | x-ray diffraction | A, B | ZN, 5ZO | — |
| 7WT1 | human glyoxalase I (with C-ter His tag) in inhibitor-free form | x-ray diffraction | A, B | ZN | 4 (best 0.63) |
| 7WT1 | Human glyoxalase I (with C-ter his tag) in inhibitor-free form | x-ray diffraction | A, B | ZN | — |
| 7WT2 | Human glyoxalase I in complex with TLSC702 | x-ray diffraction | A, B | ZN, 5ZO | — |
| Q04760 | AlphaFold monomer V2.0 prediction for lactoylglutathione lyase (Q04760) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7WT1 chain B against the predicted model Q04760: TM-score 0.99, RMSD 0.42 Å
- 1FRO chain A against the predicted model Q04760: TM-score 0.99, RMSD 0.42 Å
- 1FRO chain A against the predicted model Q04760: TM-score 0.99, RMSD 0.42 Å
- 7WSZ chain B against the predicted model Q04760: TM-score 0.99, RMSD 0.42 Å
- 7WT1 chain A against the predicted model Q04760: TM-score 0.99, RMSD 0.45 Å
- 7WT1 chain A against the predicted model Q04760: TM-score 0.99, RMSD 0.45 Å
- 3VW9 chain A against the predicted model Q04760: TM-score 0.99, RMSD 0.46 Å
- 3VW9 chain A against the predicted model Q04760: TM-score 0.99, RMSD 0.46 Å
- 3W0T chain A against the predicted model Q04760: TM-score 0.99, RMSD 0.47 Å
- 3W0T chain A against the predicted model Q04760: TM-score 0.99, RMSD 0.47 Å
Elsewhere
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