Research workbench
The flattened structure of MPIEZO1 in lipid bilayer
Analyse The flattened structure of MPIEZO1 in lipid bilayer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7WLU
- Type
- protein
- Length
- 4,494 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Piezo-type mechanosensitive ion channel component 1
- UniProt
- E2JF22
- Ligands
- PLX
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 1 distinct chain · 66% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | Piezo-type mechanosensitive ion channel component 1 | protein | 1498 | 66% helix, 6% strand | E2JF22 |
Ligands and binding sites
- PLX · (9R,11S)-9-({[(1S)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol · ligand · 3 copies · chains A, C, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1158 | 0.88 | 0.88 | 127 | empty |
| 2 | 1035 | 0.87 | 0.88 | 118 | empty |
| 3 | 1188 | 0.86 | 0.86 | 110 | empty |
| 4 | 1200 | 0.86 | 0.86 | 117 | empty |
| 5 | 603 | 0.85 | 0.90 | 52 | empty |
Interfaces
3 interfaces between chains.
- A–C · 2410 Ų buried · 18 hydrogen bonds · protein-protein
- A–E · 2409 Ų buried · 18 hydrogen bonds · protein-protein
- C–E · 2404 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 7WLU · The Flattened Structure of mPIEZO1 in Lipid Bilayer · the same entry in another collection · chain A against A, TM-score 1.00
- E2JF22 · AlphaFold monomer V2.0 prediction for piezo-type mechanosensitive ion channel component 1… · a predicted model of the same protein · chain A against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E2JF22
- Elsewhere: RCSB PDB 7WLU · PDBe 7WLU · UniProt E2JF22
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