Crystal structure of FGFR4(V550L) kinase domain with 7V

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 14% strand (DSSP).

Ligands and binding sites

• 90F · ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide · ligand · chains A
• SO4 · Sulfate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

• 7WCW · Crystal structure of FGFR4(V550L) kinase domain with 7v · the same entry in another collection · chain A against A, TM-score 1.00
• P22455 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 4 (P22455) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P22455
• Elsewhere: RCSB PDB 7WCW · PDBe 7WCW · UniProt P22455