Research workbench
Structure of the human CNOT1(MIF4G)-CNOT6L-CNOT7 complex
Analyse Structure of the human CNOT1(MIF4G)-CNOT6L-CNOT7 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VOI
- Type
- protein
- Length
- 673 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CCR4-not transcription complex subunit 7; CCR4-not transcription complex subunit 1…
- EC
- 3.1.13.4
- UniProt
- Q9UIV1, A5YKK6, Q96LI5
- Pockets
- 9 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 46% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | CCR4-not transcription complex subunit 7 (EC 3.1.13.4) | protein | 264 | 41% helix, 13% strand | Q9UIV1 |
| A | CCR4-not transcription complex subunit 1 | protein | 229 | 63% helix, 0% strand | A5YKK6 |
| C | CCR4-not transcription complex subunit 6-like (EC 3.1.13.4) | protein | 180 | 32% helix, 9% strand | Q96LI5 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 354 | 0.61 | 0.77 | 32 | empty |
| 2 | 181 | 0.56 | 0.80 | 23 | empty |
| 3 | 111 | 0.55 | 0.84 | 20 | empty |
| 4 | 147 | 0.53 | 0.81 | 30 | empty |
| 5 | 157 | 0.51 | 0.78 | 20 | empty |
Interfaces
2 interfaces between chains.
- B–A · 807 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 714 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 7VOI · Structure of the human CNOT1(MIF4G)-CNOT6L-CNOT7 complex · the same entry in another collection · chain B against B, TM-score 1.00
- A5YKK6 · AlphaFold monomer V2.0 prediction for CCR4-not transcription complex subunit 1 (A5YKK6) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9UIV1 · AlphaFold monomer V2.0 prediction for CCR4-not transcription complex subunit 7 (Q9UIV1) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q96LI5 · AlphaFold monomer V2.0 prediction for CCR4-not transcription complex subunit 6-like… · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UIV1
- Every structure of UniProt A5YKK6
- Every structure of UniProt Q96LI5
- Elsewhere: RCSB PDB 7VOI · PDBe 7VOI · UniProt Q9UIV1 · UniProt A5YKK6 · UniProt Q96LI5
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