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Crystal structure of XCAS9 P411T

Analyse Crystal structure of XCAS9 P411T in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7VK9
Type: protein
Length: 1,279 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CRISPR-associated endonuclease CAS9/CSN1
EC: 3.1.-.-
UniProt: Q99ZW2
Pockets: 20 · best druggability 0.87

Structure

x-ray diffraction · 1 distinct chain · 51% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CRISPR-associated endonuclease CAS9/CSN1 (EC 3.1.-.-)	protein	1279	51% helix, 12% strand	Q99ZW2

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	792	0.87	0.91	89	empty
2	55	0.71	0.98	21	empty
3	596	0.70	0.78	49	empty
4	293	0.69	0.83	36	empty
5	245	0.66	0.83	25	empty

Compared structures

7VK9 · Crystal structure of xCas9 P411T · the same entry in another collection · chain A against A, TM-score 1.00
Q99ZW2 · AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS9/CSN1 (Q99ZW2) · a predicted model of the same protein · chain A against A, TM-score 0.52

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99ZW2
Elsewhere: RCSB PDB 7VK9 · PDBe 7VK9 · UniProt Q99ZW2

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