UniProt Q99ZW2
CRISPR-associated endonuclease Cas9/Csn1 (Q99ZW2)
CRISPR-associated endonuclease Cas9/Csn1 (UniProt Q99ZW2), EC 3.1.-.-: 133 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 1,452 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q99ZW2
- Protein
- CRISPR-associated endonuclease Cas9/Csn1
- EC
- 3.1.-.-
- Experimental structures
- 133
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 1,452 · 74 records with a druggable one
Structures
134 records of Q99ZW2 in the MolNFT archive: 133 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4CMP | Crystal structure of S. pyogenes Cas9 | x-ray diffraction | A, B | — | — |
| 4CMP | Crystal structure of S. pyogenes CAS9 | x-ray diffraction | A, B | — | — |
| 4CMQ | Crystal structure of Mn-bound S.pyogenes Cas9 | x-ray diffraction | A, B | — | — |
| 4CMQ | Crystal structure of mn-bound S.PYOGENES CAS9 | x-ray diffraction | A, B | — | — |
| 4OO8 | Crystal structure of Streptococcus pyogenes Cas9 in complex with guide RNA and target DNA | x-ray diffraction | A, D | — | — |
| 4OO8 | Crystal structure of streptococcus pyogenes CAS9 in complex with guide RNA and target DNA | x-ray diffraction | A, D | — | — |
| 4UN3 | Crystal structure of Cas9 bound to PAM-containing DNA target | x-ray diffraction | B | — | — |
| 4UN3 | Crystal structure of CAS9 bound to pam-containing DNA target | x-ray diffraction | B | — | — |
| 4UN4 | Crystal structure of Cas9 bound to PAM-containing DNA target with mismatches at positions 1-2 | x-ray diffraction | B | — | — |
| 4UN4 | Crystal structure of CAS9 bound to pam-containing DNA target with mismatches at positions 1-2 | x-ray diffraction | B | — | — |
| 4UN5 | Crystal structure of Cas9 bound to PAM-containing DNA target containing mismatches at positions 1-3 | x-ray diffraction | B | — | — |
| 4UN5 | Crystal structure of CAS9 bound to pam-containing DNA target containing mismatches at positions 1-3 | x-ray diffraction | B | — | — |
| 5B2R | Crystal structure of the streptococcus pyogenes CAS9 vqr variant in complex with sgrna and target… | x-ray diffraction | B | — | — |
| 5B2S | Crystal structure of the streptococcus pyogenes CAS9 eqr variant in complex with sgrna and target… | x-ray diffraction | B | — | — |
| 5B2T | Crystal structure of the streptococcus pyogenes CAS9 vrer variant in complex with sgrna and target… | x-ray diffraction | B | — | — |
| 5F9R | Crystal structure of catalytically-active Streptococcus pyogenes CRISPR-Cas9 in complex with… | x-ray diffraction | B | SO4 | — |
| 5F9R | Crystal structure of catalytically-active streptococcus pyogenes CRISPR-CAS9 in complex with… | x-ray diffraction | B | — | — |
| 5FQ5 | Crystal structure of Cas9-sgRNA-DNA complex solved by native SAD phasing | x-ray diffraction | B | K | — |
| 5FQ5 | Crystal structure of CAS9-sgrna-DNA complex solved by native sad phasing | x-ray diffraction | B | — | — |
| 5FW1 | Crystal structure of SpyCas9 variant VQR bound to sgRNA and TGAG PAM target DNA | x-ray diffraction | B | K | — |
| 5FW1 | Crystal structure of SPYCAS9 variant vqr bound to sgrna and tgag pam target DNA | x-ray diffraction | B | — | — |
| 5FW2 | Crystal structure of SpCas9 variant EQR bound to sgRNA and TGAG PAM target DNA | x-ray diffraction | B | K | — |
| 5FW2 | Crystal structure of SPCAS9 variant eqr bound to sgrna and tgag pam target DNA | x-ray diffraction | B | — | — |
| 5FW3 | Crystal structure of SpCas9 variant VRER bound to sgRNA and TGCG PAM target DNA | x-ray diffraction | B | K | — |
| 5FW3 | Crystal structure of SPCAS9 variant vrer bound to sgrna and tgcg pam target DNA | x-ray diffraction | B | — | — |
| 5VW1 | Crystal structure of SpyCas9-sgRNA-AcrIIA4 ternary complex | x-ray diffraction | A | — | 20 (best 0.87) |
| 5VW1 | Crystal structure of SPYCAS9-sgrna-ACRIIA4 ternary complex | x-ray diffraction | A | — | — |
| 5XBL | Structure of nuclease in complex with associated protein | x-ray diffraction | A | — | — |
| 5Y36 | Cryo-EM structure of SpCas9-sgRNA-DNA ternary complex | electron microscopy | A | MG | — |
| 5Y36 | Cryo-EM structure of SPCAS9-sgrna-DNA ternary complex | electron microscopy | A | MG | — |
| 6AEB | Crystal structure of xCas9 in complex with sgRNA and target DNA (AAG PAM) | x-ray diffraction | B, F | — | 20 (best 0.83) |
| 6AEB | Crystal structure of XCAS9 in complex with sgrna and target DNA (aag pam) | x-ray diffraction | B, F | — | — |
| 6AEG | Crystal structure of XCAS9 in complex with sgrna and target DNA (gat pam) | x-ray diffraction | B | — | — |
| 6AI6 | Crystal structure of SPCAS9-ng | x-ray diffraction | A | K | — |
| 6IFO | Crystal structure of ACRIIA2-SPYCAS9-sgrna ternary complex | x-ray diffraction | A, B | — | — |
| 6K3Z | Crystal structure of dCas9 in complex with sgRNA and DNA (TGA PAM) | x-ray diffraction | B | — | 20 (best 0.79) |
| 6K3Z | Crystal structure of DCAS9 in complex with sgrna and DNA (tga pam) | x-ray diffraction | B | — | — |
| 6K4P | Crystal structure of xCas9 in complex with sgRNA and DNA (TGG PAM) | x-ray diffraction | B | PO4 | 20 (best 0.84) |
| 6K4P | Crystal structure of XCAS9 in complex with sgrna and DNA (tgg pam) | x-ray diffraction | B | PO4 | — |
| 6K4Q | Crystal structure of xCas9 in complex with sgRNA and DNA (CGG PAM) | x-ray diffraction | B | PO4 | 20 (best 0.83) |
| 6K4Q | Crystal structure of XCAS9 in complex with sgrna and DNA (cgg pam) | x-ray diffraction | B | PO4 | — |
| 6K4S | Crystal structure of XCAS9 in complex with sgrna and DNA (tgc pam) | x-ray diffraction | B | — | — |
| 6K4U | Crystal structure of XCAS9 in complex with sgrna and DNA (tga pam) | x-ray diffraction | B | — | — |
| 6K57 | Crystal structure of dCas9 in complex with sgRNA and DNA (CGA PAM) | x-ray diffraction | B | — | 20 (best 0.80) |
| 6K57 | Crystal structure of DCAS9 in complex with sgrna and DNA (cga pam) | x-ray diffraction | B | — | — |
| 6O0X | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | electron microscopy | A | — | 20 (best 0.78) |
| 6O0X | Conformational states of CAS9-sgrna-DNA ternary complex in the presence of magnesium | electron microscopy | A | — | — |
| 6O0Y | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | electron microscopy | A | — | 20 (best 0.84) |
| 6O0Y | Conformational states of CAS9-sgrna-DNA ternary complex in the presence of magnesium | electron microscopy | A | — | — |
| 6O0Z | Conformational states of Cas9-sgRNA-DNA ternary complex in the presence of magnesium | electron microscopy | A | — | 20 (best 0.78) |
| 6O0Z | Conformational states of CAS9-sgrna-DNA ternary complex in the presence of magnesium | electron microscopy | A | — | — |
| 6O56 | Hnh nuclease from S. pyogenes CAS9 | x-ray diffraction | A, B | — | — |
| 7OX7 | Target-bound SpCas9 complex with TRAC chimeric RNA-DNA guide | x-ray diffraction | B | MG, K | 20 (best 0.77) |
| 7OX7 | Target-bound SPCAS9 complex with trac chimeric RNA-DNA guide | x-ray diffraction | B | K | — |
| 7OX8 | Target-bound SpCas9 complex with TRAC full RNA guide | x-ray diffraction | B | MG, K | 20 (best 0.78) |
| 7OX8 | Target-bound SPCAS9 complex with trac full RNA guide | x-ray diffraction | B | K | — |
| 7OX9 | Target-bound SPCAS9 complex with AAVS1 all-RNA guide | x-ray diffraction | B | K | — |
| 7OXA | Target-bound SpCas9 complex with AAVS1 chimeric RNA-DNA guide | x-ray diffraction | B | MG, K | 20 (best 0.83) |
| 7OXA | Target-bound SPCAS9 complex with AAVS1 chimeric RNA-DNA guide | x-ray diffraction | B | K | — |
| 7QQO | SpCas9 bound to AAVS1 off-target1 DNA substrate | x-ray diffraction | B | MG, K | 20 (best 0.85) |
74 records more on the page itself.
Ligands
Experiment against prediction
- 7ZO1 chain B against the predicted model Q99ZW2: TM-score 0.99, RMSD 1.17 Å
- 6K4P chain B against the predicted model Q99ZW2: TM-score 0.99, RMSD 1.29 Å
- 6K4P chain B against the predicted model Q99ZW2: TM-score 0.99, RMSD 1.29 Å
- 7OX7 chain B against the predicted model Q99ZW2: TM-score 0.99, RMSD 1.31 Å
- 7OX7 chain B against the predicted model Q99ZW2: TM-score 0.99, RMSD 1.31 Å
- 6AI6 chain A against the predicted model Q99ZW2: TM-score 0.99, RMSD 1.32 Å
- 6K4Q chain B against the predicted model Q99ZW2: TM-score 0.99, RMSD 1.33 Å
- 6K4Q chain B against the predicted model Q99ZW2: TM-score 0.99, RMSD 1.33 Å
- 8SCA chain B against the predicted model Q99ZW2: TM-score 0.99, RMSD 0.63 Å
- 7OXA chain B against the predicted model Q99ZW2: TM-score 0.99, RMSD 1.35 Å
Elsewhere
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