Research workbench
10,5-methenyltetrahydrofolate cyclohydrolase from methylobacterium extorquens AM1 strain
Analyse 10,5-methenyltetrahydrofolate cyclohydrolase from methylobacterium extorquens… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VG4
- Type
- protein
- Length
- 1,201 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methenyltetrahydrofolate cyclohydrolase
- EC
- 3.5.4.9
- UniProt
- Q49135
- Pockets
- 15 · best druggability 0.69
Structure
x-ray diffraction · 6 distinct chains · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | protein | 204 | 83% helix, 0% strand | Q49135 |
| B | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | protein | 206 | 83% helix, 0% strand | Q49135 |
| C | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | protein | 205 | 82% helix, 0% strand | Q49135 |
| D | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | protein | 204 | 81% helix, 0% strand | Q49135 |
| E | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | protein | 196 | 82% helix, 1% strand | Q49135 |
| F | Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) | protein | 186 | 81% helix, 1% strand | Q49135 |
Pockets
15 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 338 | 0.69 | 0.82 | 40 | empty |
| 2 | 248 | 0.66 | 0.83 | 31 | empty |
| 3 | 274 | 0.66 | 0.82 | 39 | empty |
| 4 | 446 | 0.66 | 0.78 | 60 | empty |
| 5 | 300 | 0.65 | 0.81 | 33 | empty |
Interfaces
7 interfaces between chains.
- A–B · 2349 Ų buried · 22 hydrogen bonds · protein-protein
- E–F · 2348 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 2251 Ų buried · 19 hydrogen bonds · protein-protein
- A–E · 919 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 651 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7VG4 · 10,5-methenyltetrahydrofolate cyclohydrolase from Methylobacterium extorquens AM1 strain · the same entry in another collection · chain F against F, TM-score 1.00
- Q49135 · AlphaFold monomer V2.0 prediction for methenyltetrahydrofolate cyclohydrolase (Q49135) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q49135
- Elsewhere: RCSB PDB 7VG4 · PDBe 7VG4 · UniProt Q49135
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