UniProt Q49135
Methenyltetrahydrofolate cyclohydrolase (Q49135)
Methenyltetrahydrofolate cyclohydrolase (UniProt Q49135), EC 3.5.4.9: 4 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 18 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q49135
- Protein
- Methenyltetrahydrofolate cyclohydrolase
- EC
- 3.5.4.9
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 18 · 2 records with a druggable one
Structures
5 records of Q49135 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7VG4 | 10,5-methenyltetrahydrofolate cyclohydrolase from Methylobacterium extorquens AM1 strain | x-ray diffraction | A, B, C, D, E, F | — | 15 (best 0.69) |
| 7VG4 | 10,5-methenyltetrahydrofolate cyclohydrolase from methylobacterium extorquens AM1 strain | x-ray diffraction | A, B, C, D, E, F | — | — |
| 7VG5 | 10,5-methenyltetrahydrofolate cyclohydrolase from Methylobacterium extorquens AM1 with… | x-ray diffraction | A, B | THG | 3 (best 0.59) |
| 7VG5 | 10,5-methenyltetrahydrofolate cyclohydrolase from methylobacterium extorquens AM1 with… | x-ray diffraction | A, B | THG | — |
| Q49135 | AlphaFold monomer V2.0 prediction for methenyltetrahydrofolate cyclohydrolase (Q49135) | predicted | A | — | — |
Ligands
- THG · (6S)-5,6,7,8-tetrahydrofolate · in 2 records
Experiment against prediction
- 7VG4 chain A against the predicted model Q49135: TM-score 0.99, RMSD 0.47 Å
- 7VG4 chain A against the predicted model Q49135: TM-score 0.99, RMSD 0.47 Å
- 7VG4 chain D against the predicted model Q49135: TM-score 0.99, RMSD 0.50 Å
- 7VG4 chain D against the predicted model Q49135: TM-score 0.99, RMSD 0.50 Å
- 7VG4 chain C against the predicted model Q49135: TM-score 0.99, RMSD 0.52 Å
- 7VG4 chain C against the predicted model Q49135: TM-score 0.99, RMSD 0.52 Å
- 7VG4 chain B against the predicted model Q49135: TM-score 0.99, RMSD 0.56 Å
- 7VG4 chain B against the predicted model Q49135: TM-score 0.99, RMSD 0.56 Å
- 7VG5 chain A against the predicted model Q49135: TM-score 0.99, RMSD 0.66 Å
- 7VG5 chain A against the predicted model Q49135: TM-score 0.99, RMSD 0.66 Å
Elsewhere
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