Research workbench
Crystal structure of cyclosorus parasiticus chalcone synthase 1 (CPCHS1) complex with naringenin
Analyse Crystal structure of cyclosorus parasiticus chalcone synthase 1 (CPCHS1)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VEZ
- Type
- protein
- Length
- 1,564 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chalcone synthases 1
- Ligands
- NAR
- Pockets
- 13 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 40% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Chalcone synthases 1 | protein | 391 | 39% helix, 24% strand | — |
| C | Chalcone synthases 1 | protein | 390 | 41% helix, 23% strand | — |
| D | Chalcone synthases 1 | protein | 392 | 40% helix, 23% strand | — |
Ligands and binding sites
- NAR · Naringenin · ligand · 4 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1003 | 0.82 | 0.83 | 120 | NAR |
| 2 | 321 | 0.77 | 0.88 | 46 | NAR |
| 3 | 304 | 0.75 | 0.87 | 46 | NAR |
| 4 | 329 | 0.75 | 0.86 | 49 | NAR |
| 5 | 188 | 0.47 | 0.76 | 29 | empty |
Interfaces
3 interfaces between chains.
- A–D · 3584 Ų buried · 73 hydrogen bonds · protein-protein
- B–C · 3529 Ų buried · 58 hydrogen bonds · protein-protein
- A–C · 507 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7VEZ · Crystal structure of Cyclosorus parasiticus chalcone synthase 1 (CpCHS1) complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7VEZ · PDBe 7VEZ
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.