Research workbench
Crystal structure of IPAH1.4 lrr domain bound to hoil-1L ubl domain.
Analyse Crystal structure of IPAH1.4 lrr domain bound to hoil-1L ubl domain. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7V8E
- Type
- protein
- Length
- 627 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ring-type E3 ubiquitin transferase; Ranbp-type and C3HC4-type zinc finger-containing…
- EC
- 2.3.2.27, 2.3.2.31
- UniProt
- Q9AFJ5, Q9BYM8
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | Ring-type E3 ubiquitin transferase (EC 2.3.2.27) | protein | 236 | 18% helix, 13% strand | Q9AFJ5 |
| C | Ranbp-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) | protein | 78 | 23% helix, 38% strand | Q9BYM8 |
| D | Ranbp-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) | protein | 77 | 23% helix, 38% strand | Q9BYM8 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 231 | 0.48 | 0.74 | 38 | empty |
| 2 | 160 | 0.41 | 0.73 | 29 | empty |
| 3 | 65 | 0.27 | 0.72 | 16 | empty |
Interfaces
4 interfaces between chains.
- B–C · 488 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 358 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 129 Ų buried · 1 hydrogen bond · protein-protein
- C–A · 86 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 7V8E · Crystal structure of IpaH1.4 LRR domain bound to HOIL-1L UBL domain. · the same entry in another collection · chain B against B, TM-score 1.00
- Q9BYM8 · AlphaFold monomer V2.0 prediction for ranbp-type and C3HC4-type zinc finger-containing… · a predicted model of the same protein · chain C against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9AFJ5
- Every structure of UniProt Q9BYM8
- Elsewhere: RCSB PDB 7V8E · PDBe 7V8E · UniProt Q9AFJ5 · UniProt Q9BYM8
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