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Structure of the dicer-2-R2D2 heterodimer

Analyse Structure of the dicer-2-R2D2 heterodimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7V6B
Type: protein
Length: 1,678 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dicer-2, isoform a; R2D2
EC: 3.1.21.1, 3.1.26.-, 3.1.26.3, 3.6.1.3
UniProt: A1ZAW0, Q9VLW8
Pockets: 20 · best druggability 0.77

Structure

electron microscopy · 2 distinct chains · 47% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dicer-2, isoform a (EC 3.1.21.1, 3.1.26.-, 3.1.26.3, 3.6.1.3)	protein	1496	47% helix, 11% strand	A1ZAW0
B	R2D2	protein	182	46% helix, 14% strand	Q9VLW8

Pockets

20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	304	0.77	0.89	46	empty
2	553	0.69	0.79	44	empty
3	74	0.67	0.93	14	empty
4	297	0.66	0.82	37	empty
5	363	0.61	0.77	46	empty

Interfaces

1 interface between chains.

A–B · 2175 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

7V6B · Structure of the Dicer-2-R2D2 heterodimer · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A1ZAW0
Every structure of UniProt Q9VLW8
Elsewhere: RCSB PDB 7V6B · PDBe 7V6B · UniProt A1ZAW0 · UniProt Q9VLW8

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