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Cryo-EM structure of SPYCAS9-sgrna-DNA dimer

Analyse Cryo-EM structure of SPYCAS9-sgrna-DNA dimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7V59
Type: protein + DNA + RNA
Length: 3,048 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q99ZW2

Structure

electron microscopy · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, E	—	protein	1360	—	Q99ZW2
C, G	—	rna	115	—	—
D, H	—	dna	49	—	—

Compared structures

7V59 · Cryo-EM structure of spyCas9-sgRNA-DNA dimer · the same entry in another collection · chain H against H, TM-score 1.00
Q99ZW2 · AlphaFold monomer V2.0 prediction for CRISPR-associated endonuclease CAS9/CSN1 (Q99ZW2) · a predicted model of the same protein · chain E against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99ZW2
Elsewhere: RCSB PDB 7V59 · PDBe 7V59 · UniProt Q99ZW2

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