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Type 4 alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal PARKINSON'S disease patient

Analyse Type 4 alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7V49
Type: protein
Length: 180 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-synuclein
UniProt: P37840
Pockets: 1 · best druggability 0.51

Structure

electron microscopy · 1 distinct chain · 0% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, A, B	Alpha-synuclein	protein	60	0% helix, 8% strand	P37840

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	179	0.51	0.78	27	empty

Interfaces

2 interfaces between chains.

C–A · 2207 Å² buried · 37 hydrogen bonds · protein-protein
A–B · 2199 Å² buried · 36 hydrogen bonds · protein-protein

Compared structures

7V49 · Type 4 alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's… · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37840
Elsewhere: RCSB PDB 7V49 · PDBe 7V49 · UniProt P37840

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