Research workbench
Tetrahymena cst with polymerase alpha-primase
Analyse Tetrahymena cst with polymerase alpha-primase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7UY7
- Type
- protein + DNA
- Length
- 1,818 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase-associated protein of 75 kda; Telomerase-associated protein of 45 kda…
- EC
- 2.7.7.7
- UniProt
- A0PGB2, Q6JXI5, D2CVN7, D2CVN8, Q23AJ0
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 6 distinct chains · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomerase-associated protein of 75 kda | protein | 552 | 31% helix, 26% strand | A0PGB2 |
| B | Telomerase-associated protein of 45 kda | protein | 291 | 43% helix, 16% strand | Q6JXI5 |
| C | Telomerase-associated protein of 19 kda | protein | 157 | 36% helix, 27% strand | D2CVN7 |
| D | Telomerase associated protein P50 | protein | 25 | 40% helix, 8% strand | D2CVN8 |
| E | DNA polymerase (EC 2.7.7.7) | protein | 783 | 41% helix, 17% strand | Q23AJ0 |
| F | Telomere DNA | dna | 10 | — | — |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 451 | 0.83 | 0.89 | 63 | empty |
| 2 | 148 | 0.81 | 0.96 | 30 | empty |
| 3 | 205 | 0.80 | 0.94 | 37 | empty |
| 4 | 1048 | 0.80 | 0.81 | 113 | empty |
| 5 | 288 | 0.78 | 0.90 | 44 | empty |
Interfaces
9 interfaces between chains.
- A–B · 2387 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 884 Ų buried · 9 hydrogen bonds · protein-protein
- A–E · 826 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 792 Ų buried · 6 hydrogen bonds · protein-protein
- A–F · 659 Ų buried · 19 hydrogen bonds · protein-nucleic
Compared structures
- 7UY7 · Tetrahymena CST with Polymerase alpha-Primase · the same entry in another collection · chain F against F, TM-score 1.00
- Q6JXI5 · AlphaFold monomer V2.0 prediction for telomerase-associated protein of 45 kda (Q6JXI5) · a predicted model of the same protein · chain B against A, TM-score 0.52
- D2CVN8 · AlphaFold monomer V2.0 prediction for telomerase-associated protein of 50 kda (D2CVN8) · a predicted model of the same protein · chain D against A, TM-score 0.47
- A0PGB2 · AlphaFold monomer V2.0 prediction for telomerase-associated protein of 75 kda (A0PGB2) · a predicted model of the same protein · chain A against A, TM-score 0.30
- D2CVN7 · AlphaFold monomer V2.0 prediction for telomerase-associated protein of 19 kda (D2CVN7) · a predicted model of the same protein · chain C against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0PGB2
- Every structure of UniProt Q6JXI5
- Every structure of UniProt D2CVN7
- Every structure of UniProt D2CVN8
- Every structure of UniProt Q23AJ0
- Elsewhere: RCSB PDB 7UY7 · PDBe 7UY7 · UniProt A0PGB2 · UniProt Q6JXI5 · UniProt D2CVN7 · UniProt D2CVN8 · UniProt Q23AJ0
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