Research workbench

Drosophila melanogaster SETDB1-tuor domain

Analyse Drosophila melanogaster SETDB1-tuor domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7UW8
Type: protein
Length: 221 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Histone-lysine N-methyltransferase eggless
EC: 2.1.1.355
UniProt: Q32KD2
Pockets: 2 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Histone-lysine N-methyltransferase eggless (EC 2.1.1.355)	protein	221	12% helix, 41% strand	Q32KD2

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	122	0.49	0.80	19	empty
2	129	0.45	0.77	21	empty

Compared structures

7UW8 · Drosophila melanogaster setdb1-tuor domain · the same entry in another collection · chain A against A, TM-score 1.00
Q32KD2 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase eggless (Q32KD2) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q32KD2
Elsewhere: RCSB PDB 7UW8 · PDBe 7UW8 · UniProt Q32KD2

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