Research workbench
Human KV4.2-KCHIP2 channel complex in an open state, transmembrane region
Analyse Human KV4.2-KCHIP2 channel complex in an open state, transmembrane region in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7UK5
- Type
- protein
- Length
- 1,036 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel subfamily D member 2
- UniProt
- Q9NZV8
- Ligands
- K
- Pockets
- 12 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 74% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Potassium voltage-gated channel subfamily D member 2 | protein | 259 | 74% helix, 1% strand | Q9NZV8 |
Ligands and binding sites
- K · Potassium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 837 | 0.82 | 0.84 | 41 | empty |
| 2 | 690 | 0.68 | 0.75 | 57 | empty |
| 3 | 712 | 0.68 | 0.75 | 59 | empty |
| 4 | 657 | 0.67 | 0.76 | 60 | empty |
| 5 | 690 | 0.67 | 0.75 | 57 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1574 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 1573 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 1569 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 1566 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 51 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7UK5 · Human Kv4.2-KChIP2 channel complex in an open state, transmembrane region · the same entry in another collection · chain D against D, TM-score 1.00
- Q9NZV8 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily D member… · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZV8
- Elsewhere: RCSB PDB 7UK5 · PDBe 7UK5 · UniProt Q9NZV8
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