Research workbench
Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and TIAM1
Analyse Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and TIAM1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7UIQ
- Type
- protein
- Length
- 563 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CALCIUM/CALMODULIN-dependent protein kinase type II subunit alpha; T-lymphoma invasion…
- EC
- 2.7.11.17
- UniProt
- Q9UQM7, Q60610
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CALCIUM/CALMODULIN-dependent protein kinase type II subunit alpha (EC 2.7.11.17) | protein | 268 | 39% helix, 18% strand | Q9UQM7 |
| B | CALCIUM/CALMODULIN-dependent protein kinase type II subunit alpha (EC 2.7.11.17) | protein | 261 | 38% helix, 20% strand | Q9UQM7 |
| C | T-lymphoma invasion and metastasis-inducing protein 1 | protein | 19 | 21% helix, 5% strand | Q60610 |
| D | T-lymphoma invasion and metastasis-inducing protein 1 | protein | 15 | 27% helix, 0% strand | Q60610 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 557 | 0.69 | 0.78 | 44 | empty |
| 2 | 473 | 0.66 | 0.78 | 46 | empty |
| 3 | 200 | 0.51 | 0.77 | 24 | empty |
| 4 | 64 | 0.34 | 0.77 | 19 | empty |
| 5 | 67 | 0.33 | 0.76 | 19 | empty |
Interfaces
5 interfaces between chains.
- A–C · 913 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 876 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 287 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 260 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 33 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7UIQ · Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 · the same entry in another collection · chain D against D, TM-score 1.00
- Q9UQM7 · AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent protein kinase type II… · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q60610 · AlphaFold monomer V2.0 prediction for T-lymphoma invasion and metastasis-inducing protein… · a predicted model of the same protein · chain D against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UQM7
- Every structure of UniProt Q60610
- Elsewhere: RCSB PDB 7UIQ · PDBe 7UIQ · UniProt Q9UQM7 · UniProt Q60610
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