UniProt Q9UQM7
Calcium/calmodulin-dependent protein kinase type II subunit alpha (Q9UQM7)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (UniProt Q9UQM7), EC 2.7.11.17: 41 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 101 pockets. Binding sites, druggability and…
- UniProt
- Q9UQM7
- Protein
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- EC
- 2.7.11.17
- Experimental structures
- 41
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 101 · 18 records with a druggable one
Structures
42 records of Q9UQM7 in the MolNFT archive: 41 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VZ6 | Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex… | x-ray diffraction | A, B | — | — |
| 2VZ6 | Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in complex… | x-ray diffraction | A, B | — | — |
| 3SOA | Full-length human CaMKII | x-ray diffraction | A | — | — |
| 3SOA | Full-length human camkii | x-ray diffraction | A | — | — |
| 5IG3 | Crystal structure of the human CaMKII-alpha hub | x-ray diffraction | A, B, C, D, E, F | — | 6 (best 0.69) |
| 5IG3 | Crystal structure of the human camkii-alpha hub | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6OF8 | Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human… | x-ray diffraction | F, B, C, G, E, A, D | K | 10 (best 0.68) |
| 6OF8 | Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET mutant human… | x-ray diffraction | F, B, C, G, E, A, D | K | — |
| 6VZK | Crystal structure of human CaMKII-alpha (CAMK2A)kinase domain | x-ray diffraction | A | HC4 | 2 (best 0.66) |
| 6VZK | Crystal structure of human camkii-alpha (CAMK2A)KINASE domain | x-ray diffraction | A | HC4 | — |
| 6W4O | Camkii alpha-30 cryo-EM reconstruction | electron microscopy | A, B, C, D, E, F, G, I, J, K, L, M, O | — | — |
| 6W4P | Camkii alpha-30 cryo-EM reconstruction - class B | electron microscopy | A, B, C, D, E, F, G, I, J, K, L, M, H | — | — |
| 6X5G | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and LRRC7 inhibitory domain | x-ray diffraction | A | BCN | 2 (best 0.72) |
| 6X5G | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and LRRC7 inhibitory domain | x-ray diffraction | A | BCN | — |
| 6X5Q | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluA1 | x-ray diffraction | A | — | 3 (best 0.68) |
| 6X5Q | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and GLUA1 | x-ray diffraction | A | — | — |
| 7KL0 | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) | x-ray diffraction | A, B | UZD | 9 (best 0.82) |
| 7KL0 | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and GLUN2B(S1303D) | x-ray diffraction | A, B | UZD | — |
| 7KL1 | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) | x-ray diffraction | A, B | MG, ATP | 6 (best 0.88) |
| 7KL1 | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and GLUN2B(S1303D) | x-ray diffraction | A, B | MG, ATP | — |
| 7KL2 | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) | x-ray diffraction | A | — | 3 (best 0.70) |
| 7KL2 | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and GLUN2B(S1303D) | x-ray diffraction | A | — | — |
| 7REC | Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human… | x-ray diffraction | G, D, A, B, C, E, F | 7ZV, NA | 14 (best 0.72) |
| 7REC | Structure of THR354ASN, GLU355GLN, THR412ASN, ILE414MET, ILE464HIS, and PHE467MET mutant human… | x-ray diffraction | G, D, A, B, C, E, F | 7ZV, NA | — |
| 7UIQ | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 | x-ray diffraction | A, B | — | 5 (best 0.69) |
| 7UIQ | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and TIAM1 | x-ray diffraction | A, B | — | — |
| 7UIR | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 in complex with ATP | x-ray diffraction | A, B | ATP, MG | 5 (best 0.71) |
| 7UIR | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and TIAM1 in complex with ATP | x-ray diffraction | A, B | ATP, MG | — |
| 7UIS | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) | x-ray diffraction | A | — | 3 (best 0.70) |
| 7UIS | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and GLUN2B(S1303D) | x-ray diffraction | A | — | — |
| 7UJP | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B | x-ray diffraction | A, B | ADP, MG, ATP | 7 (best 0.83) |
| 7UJP | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and GLUN2B | x-ray diffraction | A, B | ADP, MG, ATP | — |
| 7UJQ | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B | x-ray diffraction | A, B | UZD | 8 (best 0.88) |
| 7UJQ | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and GLUN2B | x-ray diffraction | A, B | UZD | — |
| 7UJR | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B | x-ray diffraction | A | SO4 | 2 (best 0.68) |
| 7UJR | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and GLUN2B | x-ray diffraction | A | SO4 | — |
| 7UJS | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B in complex with ADP | x-ray diffraction | A | ADP | 2 (best 0.70) |
| 7UJS | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and GLUN2B in complex with ADP | x-ray diffraction | A | ADP | — |
| 7UJT | Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) in complex with… | x-ray diffraction | A | ATP | 3 (best 0.66) |
| 7UJT | Cocrystal structure of human camkii-alpha (CAMK2A)KINASE domain and GLUN2B(S1303D) in complex with… | x-ray diffraction | A | ATP | — |
| 9EOY | Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human… | x-ray diffraction | A, B, C, D, E, F, G | A1H6K | 11 (best 0.75) |
| Q9UQM7 | AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent protein kinase type II subunit… | predicted | A | — | — |
Ligands
- ATP · Adenosine-5'-triphosphate · in 8 records
- MG · Magnesium ion · in 6 records
- ADP · Adenosine-5'-diphosphate · in 4 records
- UZD · methyl 6-O-(heptylcarbamoyl)-beta-L-altropyranoside · in 4 records
- 7ZV · 5-hydroxydiclofenac · in 2 records
- BCN · Bicine · in 2 records
- HC4 · 4'-hydroxycinnamic acid · in 2 records
- K · Potassium ion · in 2 records
- NA · Sodium ion · in 2 records
- SO4 · Sulfate ion · in 2 records
- A1H6K · 2-[6-(4-chlorophenyl)imidazo[1,2-b]pyridazin-2-yl]ethanoic acid · in 1 record
Experiment against prediction
- 9EOY chain E against the predicted model Q9UQM7: TM-score 0.98, RMSD 0.56 Å
- 6W4O chain O against the predicted model Q9UQM7: TM-score 0.98, RMSD 0.86 Å
- 6W4P chain H against the predicted model Q9UQM7: TM-score 0.98, RMSD 0.86 Å
- 6OF8 chain G against the predicted model Q9UQM7: TM-score 0.98, RMSD 0.57 Å
- 6OF8 chain G against the predicted model Q9UQM7: TM-score 0.98, RMSD 0.57 Å
- 6W4P chain D against the predicted model Q9UQM7: TM-score 0.98, RMSD 0.61 Å
- 6W4O chain D against the predicted model Q9UQM7: TM-score 0.98, RMSD 0.61 Å
- 6W4O chain A against the predicted model Q9UQM7: TM-score 0.98, RMSD 0.63 Å
- 6W4P chain A against the predicted model Q9UQM7: TM-score 0.98, RMSD 0.63 Å
- 6W4P chain B against the predicted model Q9UQM7: TM-score 0.98, RMSD 0.64 Å
Elsewhere
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