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Ligand · FEF

FEF · (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime}

FEF, (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} (C20 H19 N3 O4, 365.4 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å…

Component
FEF
Formula
C20 H19 N3 O4
Class
ligand
Structures
8
PDB entries
4

Binding sites

FEF in 8 structures; the first of them:

  • 2VZ6 · Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in… · FEF A600 · binds LEU19, GLY20, LYS21, VAL27, ALA40, VAL73, PHE89, ASP90 and 8 more
  • 3MTL · Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804 · FEF A668 · binds LEU171, GLY172, GLU173, VAL179, ALA192, VAL224, PHE240, GLU241 and 12 more
  • 4C57 · Structure of GAK kinase in complex with a nanobody · FEF A1340 · binds LEU46, ALA47, VAL54, ALA67, LYS69, MET89, VAL99, LEU121 and 12 more
  • 4C59 · Structure of GAK kinase in complex with nanobody (NbGAK_4) · FEF A1334 · binds LEU46, ALA47, VAL54, ALA67, LYS69, VAL99, THR123, GLU124 and 9 more
  • 2VZ6 · Structure of human calcium calmodulin dependent protein kinase type II alpha (CAMK2A) in… · FEF A600 · binds LEU19, GLY20, LYS21, VAL27, ALA40, VAL73, PHE89, ASP90 and 8 more
  • 3MTL · Crystal structure of the PCTAIRE1 kinase in complex with indirubin E804 · FEF A668 · binds LEU171, GLY172, GLU173, VAL179, ALA192, VAL224, PHE240, GLU241 and 12 more
  • 4C57 · Structure of gak kinase in complex with a nanobody · FEF A1340 · binds LEU46, ALA47, VAL54, ALA67, LYS69, MET89, VAL99, LEU121 and 12 more
  • 4C59 · Structure of gak kinase in complex with nanobody (NBGAK_4) · FEF A1334 · binds LEU46, ALA47, VAL54, ALA67, LYS69, VAL99, THR123, GLU124 and 9 more

Residues it binds most

LEU 12, VAL 12, ALA 12, GLU 12, ASP 10, LYS 12, GLY 12, ASN 12, CYS 6, GLN 8 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol
  • PGO · S-1,2-propanediol

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