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Room temperature drosophila cryptochrome

Analyse Room temperature drosophila cryptochrome in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7UD0
Type: protein
Length: 1,075 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cryptochrome-1
UniProt: O77059
Ligands: FAD
Pockets: 8 · best druggability 0.86

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cryptochrome-1	protein	537	48% helix, 7% strand	O77059
B	Cryptochrome-1	protein	538	49% helix, 7% strand	O77059

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1089	0.86	0.87	97	FAD
2	862	0.84	0.86	67	FAD
3	784	0.77	0.81	60	empty
4	248	0.67	0.84	32	empty
5	100	0.56	0.85	19	empty

Interfaces

1 interface between chains.

A–B · 914 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7UD0 · Room Temperature Drosophila Cryptochrome · the same entry in another collection · chain A against A, TM-score 1.00
O77059 · AlphaFold monomer V2.0 prediction for cryptochrome-1 (O77059) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O77059
Elsewhere: RCSB PDB 7UD0 · PDBe 7UD0 · UniProt O77059

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