Research workbench
Cryoem structure of the candida albicans ARO1 dimer
Analyse Cryoem structure of the candida albicans ARO1 dimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7U5S
- Type
- protein
- Length
- 3,006 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pentafunctional arom polypeptide
- EC
- 4.2.3.4, 2.5.1.19, 2.7.1.71, 4.2.1.10, 1.1.1.25
- UniProt
- Q5AME2
- Pockets
- 20 · best druggability 0.75
Structure
electron microscopy · 2 distinct chains · 38% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pentafunctional arom polypeptide (EC 4.2.3.4, 2.5.1.19, 2.7.1.71, 4.2.1.10, 1.1.1.25) | protein | 1501 | 37% helix, 18% strand | Q5AME2 |
| B | Pentafunctional arom polypeptide (EC 4.2.3.4, 2.5.1.19, 2.7.1.71, 4.2.1.10, 1.1.1.25) | protein | 1505 | 39% helix, 18% strand | Q5AME2 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 963 | 0.75 | 0.78 | 87 | empty |
| 2 | 748 | 0.74 | 0.79 | 59 | empty |
| 3 | 1008 | 0.74 | 0.77 | 65 | empty |
| 4 | 937 | 0.73 | 0.77 | 64 | empty |
| 5 | 893 | 0.73 | 0.77 | 92 | empty |
Interfaces
1 interface between chains.
- A–B · 2057 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5AME2
- Elsewhere: RCSB PDB 7U5S · PDBe 7U5S · UniProt Q5AME2
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