UniProt Q5AME2
Pentafunctional AROM polypeptide (Q5AME2)
Pentafunctional AROM polypeptide (UniProt Q5AME2), EC 1.1.1.25, 2.5.1.19: 8 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 47 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q5AME2
- Protein
- Pentafunctional AROM polypeptide
- EC
- 1.1.1.25, 2.5.1.19, 2.7.1.71, 4.2.1.10, 4.2.3.4
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 47 · 4 records with a druggable one
Structures
9 records of Q5AME2 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6C5C | Crystal structure of the 3-dehydroquinate synthase (DHQS) domain of Aro1 from Candida albicans… | x-ray diffraction | A, B | NAD, CL | 3 (best 0.78) |
| 6C5C | Crystal structure of the 3-dehydroquinate synthase (dhqs) domain of ARO1 from candida albicans… | x-ray diffraction | A, B | NAD, CL | — |
| 7U5S | CryoEM structure of the Candida albicans Aro1 dimer | electron microscopy | A, B | — | 20 (best 0.75) |
| 7U5S | Cryoem structure of the candida albicans ARO1 dimer | electron microscopy | A, B | — | — |
| 7U5T | Structure of DHQS/EPSPS dimer from Candida albicans Aro1 | electron microscopy | A, B | — | 7 (best 0.74) |
| 7U5T | Structure of DHQS/EPSPS dimer from candida albicans ARO1 | electron microscopy | A, B | — | — |
| 7U5U | Structure of the SK/DHQase/DHSD dimer from Candida albicans Aro1 | electron microscopy | A, B | — | 17 (best 0.74) |
| 7U5U | Structure of the SK/DHQASE/DHSD dimer from candida albicans ARO1 | electron microscopy | A, B | — | — |
| Q5AME2 | AlphaFold monomer V2.0 prediction for pentafunctional arom polypeptide (Q5AME2) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6C5C chain A against the predicted model Q5AME2: TM-score 0.96, RMSD 1.40 Å
- 6C5C chain A against the predicted model Q5AME2: TM-score 0.96, RMSD 1.40 Å
- 7U5U chain B against the predicted model Q5AME2: TM-score 0.96, RMSD 1.90 Å
- 7U5U chain B against the predicted model Q5AME2: TM-score 0.96, RMSD 1.90 Å
- 6C5C chain B against the predicted model Q5AME2: TM-score 0.96, RMSD 1.49 Å
- 6C5C chain B against the predicted model Q5AME2: TM-score 0.96, RMSD 1.49 Å
- 7U5T chain B against the predicted model Q5AME2: TM-score 0.96, RMSD 1.85 Å
- 7U5T chain B against the predicted model Q5AME2: TM-score 0.96, RMSD 1.85 Å
- 7U5T chain A against the predicted model Q5AME2: TM-score 0.96, RMSD 1.85 Å
- 7U5T chain A against the predicted model Q5AME2: TM-score 0.96, RMSD 1.85 Å
Elsewhere
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