Research workbench
EPS8 SH3 domain with NLEH1 pxxdy motif
Analyse EPS8 SH3 domain with NLEH1 pxxdy motif in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TZK
- Type
- protein
- Length
- 152 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epidermal growth factor receptor kinase substrate 8; T3SS secreted effector nleh homolog
- UniProt
- Q12929, B7ULW4
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Epidermal growth factor receptor kinase substrate 8 | protein | 64 | 5% helix, 41% strand | Q12929 |
| C, D | T3SS secreted effector nleh homolog | protein | 12 | 0% helix, 0% strand | B7ULW4 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.40 | 0.75 | 24 | empty |
Interfaces
4 interfaces between chains.
- A–C · 540 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 530 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 190 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 125 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12929
- Every structure of UniProt B7ULW4
- Elsewhere: RCSB PDB 7TZK · PDBe 7TZK · UniProt Q12929 · UniProt B7ULW4
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