Research workbench
Long form D7 protein from anopheles darlingi with U46619 and serotonin bound
Analyse Long form D7 protein from anopheles darlingi with U46619 and serotonin bound in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TX8
- Type
- protein
- Length
- 1,176 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Long form D7 salivary protein
- UniProt
- B6DDQ8
- Ligands
- SRO, PUC
- Pockets
- 20 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 63% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Long form D7 salivary protein | protein | 295 | 62% helix, 3% strand | B6DDQ8 |
| B, C | Long form D7 salivary protein | protein | 294 | 64% helix, 3% strand | B6DDQ8 |
| D | Long form D7 salivary protein | protein | 293 | 65% helix, 3% strand | B6DDQ8 |
Ligands and binding sites
- SRO · Serotonin · ligand · 4 copies · chains A, B, C, D
- PUC · (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 682 | 0.72 | 0.79 | 65 | empty |
| 2 | 363 | 0.69 | 0.82 | 38 | PUC |
| 3 | 351 | 0.69 | 0.82 | 35 | PUC |
| 4 | 348 | 0.68 | 0.82 | 38 | PUC |
| 5 | 91 | 0.67 | 0.91 | 23 | SRO |
Interfaces
5 interfaces between chains.
- B–C · 686 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 649 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 337 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 309 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 18 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- 7TX8 · Long form D7 protein from Anopheles darlingi with U46619 and serotonin bound · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B6DDQ8
- Elsewhere: RCSB PDB 7TX8 · PDBe 7TX8 · UniProt B6DDQ8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.